Vaccination, Antimicrobials and Resistance

Vaccination, Antimicrobials and Resistance

In-Unit Assessment

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COVID-19 vaccines have been licensed in more than 49 countries so far, and mass vaccination is ongoing. Three main vaccines are in use in the United Kingdom, COVID-19 mRNA Vaccine BNT162b2 (Pfizer), AZD1222 (ChAdOx1) (AstraZeneca), and mRNA-1273 (Moderna).

Answer the following questions, which relate to these newly developed vaccines.

a) What is the novel technology used in these vaccines, how do they work and how do they differ from each other? Supplement your answer with a figure or table to help explain/summarise the key differences between the three vaccines. (60/100)

b) Which of the three vaccines would be the most appropriate for use in vaccination programs in developing countries, and why? (15/100)

c) There is a great discussion regarding some SARS-CoV-2 (COVID-19) genetic variants in circulation. Why are they a potential concern for vaccination programs? (25/100)

You should support your answer by appropriate references. The word limit for this assessment (all three questions) is 1500 words (+/- 10%), not including references and figure legends. Tables are included in the word count. You will be penalised for going over the word limit but no penalties for going under the word limit.

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